发明名称 |
Methods for modulation of oocyte activation |
摘要 |
Nitric oxide synthase and nitric-oxide-related bioactivity are shown to be necessary and sufficient for activation of an oocyte during the process of fertilization. Methods are provided for the modulation of oocyte activation through modulation of nitric oxide levels. Oocyte activation is enhanced by the addition of nitric oxide synthase, nitric oxide synthase activators, nitric oxide donors, or other compounds that increase the nitric oxide levels of the oocyte during fertilization. The administration of NOS inhibitors is used to block oocyte activation, where contraception is desired.
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申请公布号 |
US2002106360(A1) |
申请公布日期 |
2002.08.08 |
申请号 |
US20000733266 |
申请日期 |
2000.12.08 |
申请人 |
BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY & CORNELL RESEARCH FOUNDATION INC |
发明人 |
KUO RICHARD;EPEL DAVID;BAXTER GREGORY |
分类号 |
A61K31/00;A61K31/04;A61K31/22;C12N5/08;(IPC1-7):A61K38/44 |
主分类号 |
A61K31/00 |
代理机构 |
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