摘要 |
<p>Radiopharmaceutical compositions which are stabilized by addition of a hydrophilic thioether, a hydrophilic 6-hydroxy-chroman derivative, or a mixture of a hydrophilic thioether and a hydrophilic 6-hydroxy-chroman derivative. specific hydrophilic thioethers of the present invention include D-methiionine, L-methionine, D-ethionine, L-ethionine, 3-methylthio-1,2-propanediol, methyl-3-(methylthio)propionate, 2-(ethylthio)ethylamine•HC1,2-(methylthio)-rthanol, buthionine, S-methyl-L-cysteine, S-methyl-D-cysteine, D-methioninol, L-methioninol, and the like. Preferably, the hydrophilic thioether used in the compositions of the invention is methioninol, 2-(ethylthio)-ethylamine•HC1,3-methythio-1,2-propanediol, or methionine. More preferably, the hydrophilic thioether used in the compositions of the invention is 2-(ethylthio)-ethylamine•HC1 or methionine. Exemplary hydrophilic 6-hydroxy-chroman derivatives of the present invention include 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox ®, available from Aldrich Chemical Co., (milwaukee, Wisconsin, USA);6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid-4-sulfonic acid; 6-hydroxy-2,5-7,8-tetramethylchroman-3-hydroxy-2-carboxylic acid; 6-hydroxy-2,5,7,8-tetramethylchroman-2-glucosamine, and 6-hydroxy-2,5,7,8-tetramethylchroman-2-(carboxy-seryl-serylamide), preferably, the hydrophilic 6-hydroxy-chroman derivative of the present invention is a water soluble vitamin E derivative.</p> |