发明名称 |
Treatment and prevention of mental diseases mediated by elevated lyso paf levels with paf antagonists |
摘要 |
The invention refers to the treatment of lyso-paf-mediated diseases with paf antagonists and a procedure for determining their efficacy. According to the invention for treating a disease caused by lyso paf ( 1-0-alkyl-sn-glyceryl-3-phosphocholine) as the precursor and metabolit of paf is found in elevated amounts in the liquor of mental and/or inflammatory diseases. Lyso paf regulates via its own receptor the paf receptors on human neutrophils which are then inhibited by paf antagonists. According to the invention for treating a mental and/or inflammatory diseases caused by lyso paf an effective amount of at least one paf antagonist is administered to a subject requiring said treatment, wherein the paf antagonist is a hydrophilic or non-hydrophilic triazolothieno-diazepine or a homologue thereof, a ginkgolide, a ginkgolide mixture or a synthetic ginkgolide derivate, or an analogue of the paf or a mixture with/of these compounds. <IMAGE> |
申请公布号 |
EP0540767(B1) |
申请公布日期 |
2002.08.07 |
申请号 |
EP19910118745 |
申请日期 |
1991.11.04 |
申请人 |
KORTH, RUTH-MARIA, DR. MED |
发明人 |
KORTH, RUTH-MARIA, DR. MED |
分类号 |
A61K31/34;A61K31/00;A61K31/365;A61K31/55;A61K45/00;A61K45/06;A61P1/14;A61P25/18;A61P25/20;A61P35/00;A61P43/00;C07D493/22;C07D495/14;C07D513/22;G01N33/50 |
主分类号 |
A61K31/34 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|