| 摘要 |
PURPOSE: A microgranular composition obtained by mixing lactic acid bacteria, a mucosa-adherent polymer and an excipient or coating the mixture as a seed with a special water-based coating base is provided. Whereby, the death rate(or death ratio) of lactic acid bacteria is reduced in the process for manufacturing coating granules and the lactic acid bacteria are stably protected from gastric acid and bile acid. CONSTITUTION: This composition contains: a seed including 10 to 90% by weight of lactic acid bacteria, 1 to 80% by weight of a mucosa-adherent polymer and 1 to 80% by weight of an excipient; and a water-based coating layer formed from 1 to 80% by weight of a water-based coating base material, based on the total weight of the seed. The lactic acid bacteria are one or more selected from the group consisting of Streptococcus, Lactococcus, Leuconostoc, Pediococcus, Enterococcus, Lactobacillus and Bifidobacterium.
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