| 摘要 |
<p>Isolated nucleic acid molecules, i.e., DNA or RNA encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing said DNA, methods for producing α and β subunits and recombinant (i.e., isolated or substantially pure) α subunits and β subunits are provided. In addition, cells expressing various multimeric combinations of subunits (i.e., α1 α2 α3 α4 α5 α6 and/or α7 in combination with at least one of an α and β subunit are also provided. A recombinant, non-human cell line expressing the human α7 subunit of nAChR is also disclosed.</p> |
