| 摘要 |
<p>Disclosed herein are systemic formulations comprising beta-carotene and derivatives thereof and a solubilizer selected from tetrahydrofuran (THF), polyethylene glycol (PEG), and mixtures thereof. Generally, the formulations are administered to animals in need thereof in therapeutically effective amounts of beta-carotene and derivatives thereof for the purpose intended. The solubilizers greatly enhance the bioavailability of beta-carotene administered systemically. Another embodiment of the present invention is a method for administering beta-carotene and derivatives thereof to an animal in need thereof by administering the formulation of the present invention. Yet another embodiment is a method for treating an animal in need thereof by administering a therapeutically effective amount of the formulation of the present invention. The invention includes a method for treating an animal suffering from or susceptible to sepsis by administering an effective amount for treating sepsis of the formulation of the present invention.</p> |
