发明名称 |
A SUSPENSION COMPRISING FIBRINOGEN, THROMBIN AND ALCOHOL, A METHOD FOR PREPARING SUCH SUSPENSION, A METHOD FOR COATING A CARRIER WITH SUCH A SUSPENSION, A METHOD OF DRYING A COATING OF A CARRIER, AND A COATED COLLAGEN SPONGE |
摘要 |
A suspension of fibrinogen, thrombin, alcohol and optionally aprotinin is obtained by mixing fibrinogen in alcohol with thrombin in alcohol. The suspension contains fibrinogen and thrombin particles with a Folk Ward mean diameter of 25 - 100 ñm. The thrombin may be human, bovine or recombinant. The fibrinogen may be human or recombinant. A method for coating a carrier, such as a collagen sponge, with the suspension, and a method for drying the coating is disclosed. The coated collagen carrier may be used as a ready-to-use absorbable composition for tissue gluing, tissue sealing and haemostasis wherein the carrier is coated with solidly fixed components of fibrin glue, i.e. fibrinogen and thrombin. |
申请公布号 |
WO02058750(A2) |
申请公布日期 |
2002.08.01 |
申请号 |
WO2002IB01454 |
申请日期 |
2002.01.25 |
申请人 |
NYCOMED PHARMA AS;SCHAUFLER, ALFRED |
发明人 |
SCHAUFLER, ALFRED |
分类号 |
A61K9/16;A61K35/16;A61K38/46;A61K38/48;A61K47/34;A61K47/36;A61K47/38;A61K47/42;A61L;A61L15/16;A61L15/22;A61L15/32;A61L15/42;A61L15/44;A61L15/64;A61L24/00;A61L24/08;A61L24/10;A61L27/00;A61L31/04;A61P7/04;A61P41/00;C08H1/06;C08J;C08J9/30;C08L;C08L89/06 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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