| 发明名称 |
CONSTITUTIVELY DESENSITIZED G PROTEIN-COUPLED RECEPTORS |
| 摘要 |
The present invention relates to modified G-protein coupled receptors (GPCRs ). The modified GPCRs of the present invention include GPCRs that have been modified to have altered DRY motifs such that the modified GPCRs are constitutively desensitized. As such, the modified GPCRs of the present invention preferably localize to endocytic vesicles or endosomes in an agoni st- independent manner. The invention also relates to methods of screening compounds and sample solutions for GPCR activity using the modified GPCRs.</ SDOAB>
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| 申请公布号 |
CA2435047(A1) |
申请公布日期 |
2002.08.01 |
| 申请号 |
CA20022435047 |
申请日期 |
2002.01.23 |
| 申请人 |
DUKE UNIVERSITY |
发明人 |
WILBANKS, ALYSON;CARON, MARC G.;BARAK, LARRY S.;OAKLEY, ROBERT H.;LAPORTE, STEPHANE A. |
| 分类号 |
A01K67/027;A61K31/41;A61K31/417;A61K31/437;A61K31/64;A61K38/00;A61K45/00;A61P1/00;A61P1/04;A61P3/04;A61P3/10;A61P9/00;A61P9/04;A61P9/06;A61P9/10;A61P9/12;A61P11/06;A61P11/08;A61P13/12;A61P25/00;A61P25/16;A61P25/22;A61P25/24;A61P25/28;A61P27/06;A61P27/16;A61P29/00;A61P31/00;A61P35/00;A61P37/08;A61P43/00;C07D233/24;C07D471/04;C07K14/705;C07K14/72;C07K16/28;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/12;C12P21/08;C12Q1/02;C12Q1/68;G01N33/15;G01N33/50;G01N33/53;G01N33/577;(IPC1-7):C12N15/12;G01N33/566;C12N15/63;A61K31/708 |
主分类号 |
A01K67/027 |
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