INDANYL-SUBSTITUTED BENZOLE CARBONAMIDE, METHOD FOR THE PRODUCTION OF THE SAME, USE THEREOF AS A MEDICAMENT AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME.

摘要

The invention relates to compounds of formula (I), wherein R(1) to R(8) have the meanings given in the claims. Said compounds act upon the Kv1.5 potassium canal and inhibit a potassium flux, known as an "ultra-rapidly activating delayed rectifier" in the human atrium. The compounds are therefore particularly suitable for use as novel anti-arrhythmic active ingredients, in particular, for the treatment and prophylaxis of atrial arrhythmia, e.g. atrial fibrillation (AF) or atrial flutter.