发明名称 |
Artificial chromosomes generated by culturing cells with dicentric chromosomes |
摘要 |
A method for producing artificial chromosomes by introducing one or more DNA fragments into a cell, comprising a selectable marker and DNA from a rDNA unit. The cells are grown under selective conditions to produce cells that have been incorporated the DNA fragment or fragments into their genomic DNA; and selecting a cell that comprises a satellite artificial chromosome. The artificial chromosomes preferably do not contain any genetic information, but do contain only non-protein encoding gene sequences such as rDNA sequences for use as vectors for delivery of DNA to mammalian hosts.
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申请公布号 |
NZ503055(A) |
申请公布日期 |
2002.07.26 |
申请号 |
NZ19970503055 |
申请日期 |
1997.04.10 |
申请人 |
CHROMOS MOLECULAR SYSTEMS, INC |
发明人 |
HADLACZKY, GYULA;SZALAY, ALADAR A |
分类号 |
A01H1/00;A01H5/00;A01K67/027;A61K38/00;A61K48/00;C12N5/10;C12N15/09;C12N15/113;C12N15/62;C12N15/82;C12N15/85;(IPC1-7):C12N15/90;C12N15/08 |
主分类号 |
A01H1/00 |
代理机构 |
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代理人 |
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