| 发明名称 |
SYMMETRICALLY DISUBSTITUTED AROMATIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING POLY (ADP-RIBOSE) GLYCOHYDROLASE, AND METHODS FOR THEIR USE |
| 摘要 |
Symmetrically disubstituted aromatic compounds and pharmaceutical compositio ns containing such compounds that inhibit and/or modulate the activity of poly(ADP-ribose) glycohydrolase, also known as PARG, are described. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorder s described herein, by administering effective amounts of such compounds.</SDO AB>
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| 申请公布号 |
CA2434636(A1) |
申请公布日期 |
2002.07.25 |
| 申请号 |
CA20012434636 |
申请日期 |
2001.04.10 |
| 申请人 |
GUILFORD PHARMACEUTICALS, INC. |
发明人 |
FERRARIS, DANA V.;KLETZLY, PAUL W.;WANG, ERIC YANJUN;LI, WEIXING;LI, JIA-HE;XING, AMY D.;ZHANG, JIE;XU, WEIZHENG |
| 分类号 |
C07D295/10;A61K9/10;A61K9/107;A61K9/20;A61K9/48;A61K31/136;A61K31/166;A61K31/18;A61K31/216;A61K31/277;A61K31/352;A61K31/39;A61K31/4025;A61K31/444;A61K31/4545;A61K31/496;A61K31/5377;A61K47/30;A61P1/00;A61P1/04;A61P3/00;A61P3/10;A61P7/00;A61P9/00;A61P9/10;A61P13/12;A61P17/00;A61P17/02;A61P19/02;A61P19/10;A61P21/04;A61P25/00;A61P25/02;A61P27/02;A61P29/00;A61P31/04;A61P37/04;A61P43/00;C07C69/00;C07C69/76;C07C211/45;C07C225/16;C07C233/65;C07C233/66;C07C233/69;C07C233/73;C07C255/46;C07C311/37;C07C311/46;C07D207/32;C07D207/325;C07D213/30;C07D213/40;C07D295/12;C07D295/13;C07D295/18;C07D295/192;C07D311/82;C07D311/86;C07D327/08;C07D411/12;C07D411/14;(IPC1-7):C07C69/00;A61K31/235 |
主分类号 |
C07D295/10 |
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