| 发明名称 |
ANTISENSE MODULATION OF TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME (TACE) EXPRESSION |
| 摘要 |
<p>Compositions and methods are provided for inhibiting the expression of human tumor necrosis factor-alpha-converting enzyme (TACE). Antisense oligonucleotides targeted to nucleic acids encoding TACE are preferred. Methods of using these oligonucleotides for inhibition of TACE expression and for treatment of diseases, particularly inflammatory and autoimmune diseases, associated with overexpression of TACE or TNF-alpha are provided.</p> |
| 申请公布号 |
EP1223988(A1) |
申请公布日期 |
2002.07.24 |
| 申请号 |
EP20000971012 |
申请日期 |
2000.10.23 |
| 申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
FLOURNOY, SHIN, CHENG;BENNETT, C., FRANK |
| 分类号 |
C12N15/09;A61K9/10;A61K31/7088;A61K31/7115;A61K31/712;A61K38/00;A61K48/00;A61P1/00;A61P1/16;A61P1/18;A61P3/10;A61P17/00;A61P17/06;A61P19/02;A61P25/00;A61P29/00;A61P31/00;A61P35/00;A61P37/02;A61P43/00;C07H19/06;C07H19/10;C07H19/16;C07H19/20;C07H21/04;C12N15/113;C12Q1/02;C12Q1/68;(IPC1-7):A61K48/00;C07H21/02;C12P19/34 |
主分类号 |
C12N15/09 |
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