发明名称 |
Nitroimidazole ester analogues and therapeutic applications |
摘要 |
Novel nitroimidazole compounds are provided that have a substituent linked via an ester linkage. The ester linkage may be obtained by derivation of the hydroxyl group of metronidazole. These nitroimidazole ester analogs have anti-microbial activity, with a number of novel compounds having an anti-microbial activity that is significantly improved with respect to metronidazole. Two particularly preferred embodiments are shown by Formulas 4 and 5 below:
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申请公布号 |
US6423707(B1) |
申请公布日期 |
2002.07.23 |
申请号 |
US20000650027 |
申请日期 |
2000.08.28 |
申请人 |
CALIFORNIA PACIFIC MEDICAL CENTER |
发明人 |
YANG LI-XI;WANG HUI-JUAN;PAN XIANDAO |
分类号 |
C07D233/94;C07D401/12;C07D405/12;C07D409/12;C07D417/12;C07D491/04;(IPC1-7):A61K31/54;A61K31/47;C07D279/36;C07D215/00;C07D233/02 |
主分类号 |
C07D233/94 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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