发明名称 Inhibiting oxidative degradation of pharmaceutical formulations
摘要 The invention provides methods for inhibiting oxidative degradation of pharmaceutical formulations comprising at least one oxidation-susceptible active drug ingredient which methods comprise adding an oxidation-inhibiting amount of a ferrous ion source, preferably in the form of a pharmaceuticalexcipient, to the formulation.The invention further provides pharmaceutical formulations comprising at least one oxidation-susceptible active drug ingredient and an oxidation-inhibiting amount of a ferrous iron source, preferably in the form of a pharmaceuticalexcipient.The invention still further provides for the use of a ferrous ion source as an anti-oxidant in pharmaceutical formulations.
申请公布号 US6423351(B2) 申请公布日期 2002.07.23
申请号 US20010803455 申请日期 2001.03.09
申请人 PFIZER INC. 发明人 WANG HAI
分类号 A61K9/00;A61K47/02;A61K47/12;(IPC1-7):A61K33/26;A61K31/295;A61K31/40;A61K31/439 主分类号 A61K9/00
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