| 摘要 |
PROBLEM TO BE SOLVED: To provide a new sulfone derivative having anti-blood-coagulative activity and antithrombotic activity through inhibiting activated blood coagulation factor X (FXa), thus useful for preventing and treating arterial and venous thromboembolismic diseases, inflammation, cancer, etc., to provide a method for producing the above sulfone derivative, and to provide applications of the above sulfone derivative. SOLUTION: This new sulfone derivative is a compound of the formula (wherein, R is a cyclic hydrocarbon group or the like; W is a valence bond; X is a bivalent hydrocarbon group or the like; Y and Z are each a group N(R6) or the like; ring A is a nitrogen-containing heterocyclic ring or the like; R5 and R6 are each H, a hydrocarbon group or the like; Z' is an imidoyl group or the like; (a) is 0, 1 or 2; and b is 0 or 1) or a salt thereof. |
