发明名称 |
Non-invasive approach for assessing tumors in living animals |
摘要 |
A means for following the growth of experimental neoplasms involves administering recombinant tumor cells containing an expression construct encoding a secretable marker to an experimental animal and measuring secreted marker in the urine of animals bearing tumors formed by such recombinant tumor cells. Urinary marker levels are quantitatively related to tumor loads. Urinary marker can be detected before tumors are grossly visible or clinically apparent. Marker levels decrease following surgical excision or chemotherapeutic treatment, with an estimated half-life of 11 hours. This approach is applicable to the study of many experimental tumor systems.
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申请公布号 |
US6419896(B1) |
申请公布日期 |
2002.07.16 |
申请号 |
US20000517740 |
申请日期 |
2000.03.03 |
申请人 |
VOGELSTEIN BERT;KINZLER KENNETH W.;SHIH LE-MING |
发明人 |
VOGELSTEIN BERT;KINZLER KENNETH W.;SHIH LE-MING |
分类号 |
G01N33/574;G01N33/76;(IPC1-7):A61K49/00;C12Q1/00;C12P21/06 |
主分类号 |
G01N33/574 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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