Compositions and methods for treating glomerular disorders

摘要

Compositions and methods comprising an agent that reduces proteinuria in an individual are disclosed. Compositions and methods comprise an agent that reduces availability of a catalytic iron source in glomeruli. Agents of the invention include inhibitors of members of the cytochrome P450 (CYP) superfamily. In a particularly preferred embodiment, compositions and methods comprise an agent that inhibits ability of a CYP superfamily member to serve as a glomerular catalytic iron source, thereby reducing proteinuria in an individual afflicted with a glomerular disease.