| 摘要 |
<p>A process for producing prenyl alcohol characterized by comprising culturing mutated cells having been mutated so as to reduce the amount of the transcriptional product of squalene synthase gene having a translation activity and then collecting prenyl alcohol from the culture medium thus obtained. To reduce the amount of the transcriptional product, mutated cells, wherein the transcriptional promoter domain of the squalene synthase has been substituted by a transcription inhibitory promoter such as GAL1, are cultured under transcription inhibitory conditions. Moreover, a process comprising constructing a recombinant by transferring an expression DNA or a genome integration DNA containing an isopentenyl diphosphate synthesis pathway-associated enzyme gene, culturing the obtained recombinant and then collecting prenyl alcohol from the culture medium is provided.</p> |
