发明名称 |
A METHOD FOR THE MANUFACTURE OF COMPOSITIONS CONTAINING LOW CONCENTRATIONS OF SALTS |
摘要 |
Method for desalting an aqueous liquid containing a charged substance comprising the steps of:(i) contacting liquid (I) with an ion-exchanger (1) under conditions permitting binding between ion-exchanger and substance, sai d ion-exchanger comprising a base matrix carrying an ion-exchange ligand (Liga nd 1) with the opposite charge compared to the substance, (ii) desorbing said substance from said ion-exchanger by the use of a liquid (liquid (II)). Wherein: (A) ion-exchanger (1) is an ion-exchanger::(a) that can bind the substance in an aqueous reference liquid at an ionic strength corresponding to 0.1 M NaCl, preferably 0.25 M NaCl; and (b) permits a breakthrough capacity at the pH provided by liquid (I) which is more than 2 mg/ml of gel, at a breakthrough of 10% and linear flow velocity of 300 cm/h;and(B) in step (ii) the pH of liquid (II) is adjusted to a pH value where the charge difference between the substance, the ligand and/or the ion-exchanger is lowered.</SDOA B> |
申请公布号 |
CA2431662(A1) |
申请公布日期 |
2002.07.11 |
申请号 |
CA20012431662 |
申请日期 |
2001.12.19 |
申请人 |
AMERSHAM BIOSCIENCES AB |
发明人 |
MALOISEL, JEAN-LUC;JOHANSSON, BO-LENNART;BELEW, MAKONNEN |
分类号 |
A23L33/00;A61K38/00;A61K39/395;A61P7/00;A61P37/00;B01J39/04;B01J39/26;B01J41/04;B01J41/20;B01J47/14;B01J49/00;C02F1/42;C07K1/18 |
主分类号 |
A23L33/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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