发明名称 |
Process for preparing 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl-acetic acid |
摘要 |
The present invention relates to a process process for the preparation of the compound of the formula Iwhere the compound of the formula IIIis reacted with oxalyl chloride and the product obtained is treated with hydrazine and an alkali metal hydroxide in the aqueous phase at elevated temperature, after treatment is complete a three-phase system is produced by addition of an ether and the compound of the formula I is obtained by acidifying the middle phase.The invention moreover relates to a polymorph of the compound of the formula I.
|
申请公布号 |
US6417371(B1) |
申请公布日期 |
2002.07.09 |
申请号 |
US20010769742 |
申请日期 |
2001.01.26 |
申请人 |
MERCKLE GMBH |
发明人 |
KAMMERMEIER THOMAS;LAUFER STEFAN;MERCKLE PHILIPP;STRIEGEL HANS-GUENTER |
分类号 |
A61K31/407;A61P3/06;A61P7/02;A61P11/08;A61P17/00;A61P17/04;A61P17/06;A61P19/02;A61P29/00;A61P35/04;A61P37/08;A61P43/00;C07D487/04;(IPC1-7):C07D209/52;A61K31/40 |
主分类号 |
A61K31/407 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|