The present invention provides a method of selecting binding pair members with enhanced binding affinity for the cognate binding partner relative to a reference binding pair member (see Figure 2). In particular, the invention provides methods of selecting antibodies with enhanced affinity for antigen relative to a reference antibody. This process, "affinity maturation", thereby provides antibodies with superior binding capabilities.
申请公布号
WO0236738(A3)
申请公布日期
2002.07.04
申请号
WO2001US45371
申请日期
2001.10.30
申请人
HORIZON BIOTECHNOLOGIES, INC.;BALINT, ROBERT, F.;HER, JENG-HORNG;LARRICK, JAMES, W.
发明人
BALINT, ROBERT, F.;HER, JENG-HORNG;LARRICK, JAMES, W.