PROSTAGLANDIN DERIVATIVES

摘要

A prostaglandin derivative represented by the formula: <CHEM> Äwherein X is CH2, O or S(O)q1, Y is an ethylene group, a vinylene group, an ethynylene group, O(CH2)tl or S(O)q2(CH2)tl, Z is an ethylene group, a vinylene group or an ethynylene group, R<1> is a hydrogen atom, a C1-10 alkyl group or a C3-10 cycloalkyl group, R<2> is a C1-10 alkyl group, a C2-10 alkenyl group, a C2-10 alkynyl group, a C3-10 cycloalkyl group, a C1-5 alkyl-C3-10 cycloalkyl group, a C3-10 cycloalkyl-C1-5 alkyl group, a hydroxy-C1-5 alkyl group, a halogeno-C1-5 alkyl group, a C1-5 alkoxy-C1-5 alkyl group, a C2-4 alkoxycarbonyl-C1-5 alkyl group, a carboxyl-C1-5 alkyl group, a cyano-C1-5 alkyl group, a C1-5 alkyl group substituted with a group represented by the formula: -NR<7>R<8>, an acyl group, a group represented by the formula: -(CH2)t2CH(NH2)COOR<9>, etc., and R<3> is a hydrogen atom, a C1-10 alkyl group, etc.Ü, a pharmaceutically acceptable salt thereof or a hydrate thereof. Novel prostaglandin derivatives of the present invention have an excellent action in inhibiting the growth of vascular smooth muscle, and are useful as drugs for prevention or treatment of the restenosis after PTCA, etc.