发明名称 SYNTHETIC ANALOGS OF ECTEINASCIDIN-743.
摘要 <p>The present invention is directed to the synthesis and characterization of compounds having formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are each independently selected from the group consisting of H, OH, OR', SH, SR', SOR', SO2R', NO2, NH2, NHR', N(R')2, NHC(O)R', CN, halogen, =O, C(=O)R', CO2H, CO2R', C1-C12alkyl, C2-C12 alkenyl, C2-C12alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, and substituted or unsubstituted heteroaromatic; wherein each of the R' groups is independently selected from the group consisting of H, OH, NH2, NO2, SH, CN, halogen, =O, C(=O)H, C(=O)CH3, CO2H, CO2CH3, C1-C12alkyl, C2-C12alkenyl, C2-C12alkynyl, aryl, aralkyl, and heteroaromatic; wherein each dotted circle represents one, two or three optional double bonds; wherein R7 and R8 may be joined into a carboxyclic or heterocyclic ring system; and wherein X1 and X2 are each independently defined as above for R1-R8, and each further includes specific preferred groups as defined herein.</p>
申请公布号 MXPA01003339(A) 申请公布日期 2002.07.02
申请号 MX2001PA03339 申请日期 1999.09.30
申请人 PRESIDENT AND FELLOWS OF HARVARD COLLEGE 发明人 COREY, ELIAS, J.
分类号 A61K31/4995;A61P35/00;C07D471/18;C07D491/22;(IPC1-7):A01N43/58;C07D241/36 主分类号 A61K31/4995
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