发明名称 |
Polymer composition for delivering a nucleic acid or derivative thereof |
摘要 |
A composition for delivering a biologically active polyanionic molecule comprising a linear polymer with a backbone comprising amido and tertiary amino groups arranged regularly on the backbone and biologically active polyanionic molecule bound to the polymer. Preferably, the linear polymer comprises a poly(amidoamine). Preferably, the biologically active polyanionic molecule is a nucleic acid, more preferably a DNA. The compositions are useful for delivering nucleic acids to a cell in a cell transformation, transfection or gene therapy method.
|
申请公布号 |
US6413941(B1) |
申请公布日期 |
2002.07.02 |
申请号 |
US19980101254 |
申请日期 |
1998.08.03 |
申请人 |
WEST PHARMACEUTICAL SERVICES DRUG DELIVERY & CLINICAL RESEARCH CENTRE LIMITED |
发明人 |
GARNETT MARTIN CHARLES;MACLAUGHLIN FIONA CAROLINE;DAVIS STANLEY STEWART;BIGNOTTI FABIO;FERRUTI PAOLO |
分类号 |
A61K9/00;A61K31/70;A61K47/34;A61K47/48;A61K48/00;(IPC1-7):A61K31/70 |
主分类号 |
A61K9/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|