(1R,1'R)-ATRACURIUM SALTS SEPARATION PROCESS

摘要

The present invention provides an improved method of chromatographically separating the isomers of (lR,rR)-atracurium salts by high-performance liquid chromatography (HPLC), in the absence of a strong acid. The separation is preferably performed on a silica gel HPLC column using an eluent containing an organic solvent, a polar aprotic co-solvent and a weak organic acid.