发明名称 |
Process for labeling a nucleic acid |
摘要 |
A process of fragmenting and labeling a synthetic or natural nucleic acid, comprising the steps of providing a mixture containing a nucleic acid, a labeling agent containing a detectable label, and at least one multivalent metal cation in a substantially aqueous solution; chemically fragmenting the nucleic acid in the mixture to produce a multiplicity of nucleic acid fragments; and attaching at least one label to at least one of the nucleic acid fragments to produce a detectably labeled nucleic acid fragment.
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申请公布号 |
US2002081586(A1) |
申请公布日期 |
2002.06.27 |
申请号 |
US20000736151 |
申请日期 |
2000.12.15 |
申请人 |
LAAYOUN ALI;MENOU LIONEL;TORA CHRISTELLE;BANERJEE ALOKE R.;BECKER MICHAEL M.;BROWNE KENNETH A.;FRIEDENBERG MATTHEW C.;HAJJAR FRED F. |
发明人 |
LAAYOUN ALI;MENOU LIONEL;TORA CHRISTELLE;BANERJEE ALOKE R.;BECKER MICHAEL M.;BROWNE KENNETH A.;FRIEDENBERG MATTHEW C.;HAJJAR FRED F. |
分类号 |
C07H21/00;(IPC1-7):C12Q1/68;C12P19/34;C07H21/02;C07H21/04 |
主分类号 |
C07H21/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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