SUBSTITUED OXAZOLES AND THIAZOLES AS HPPAR ALPHA AGONISTS

摘要

Compounds of formula (I) and pharmaceutically acceptable salts, solvates and hydrolysable esters thereof wherein X is O or S; X1 is O or S; X is S or O; R?1 and R2¿ are independently H, methyl, or halogen; R?4 and R5¿ are independently H or C¿1-3? alkyl or R?4 and R5¿ may, together with the carbon atom to which they are bonded, form a 3-5 membered cycloalkyl ring; R?6 and R7¿ are independently H, C¿1-3? alkyl, or allyl; each R?3¿ is independently halogen, C¿1-6? straight or branched alkyl, or CF3; and y is 0, 1, 2, 3, 4 or 5 act as hPPAR alpha agonists.