PTERIDINE DERIVATIVE AS THERAPEUTIC AGENT FOR HUMAN B TYPE HEPATITIS

摘要

PURPOSE: A pteridine derivative is provided which is obtained by culturing Streptomyces sp. DWJJ 839 and purification, and shows excellent inhibiting effect on HBV polymerase. Therefore, it can be effectively used as a therapeutic agent for B type hepatitis and formulated into injection, ointment, cream, liquid, etc. CONSTITUTION: Streptomyces sp. DWJJ 839(KFCC 10974) separated from soil is cultured, the culture solution thereof is heat treated and centrifuged to separate a supernatant, the concentrated supernatant is extracted in butanol, purified with column chromatography and separated with HPLC to produce a pteridine derivative of the formula(1-1). In formula, R5 and R6 are CH3; X1 and X2 are nitrogen; X3 and X4 are oxygen. The therapeutic agent for B type hepatitis contains a pteridine derivative of the formula(1) or a salt thereof. In formula, R1 and R2 are each H, C1-4 alkyl or lower alkoxy or can form a benzene ring by binding R1 and R2.