发明名称 Liquid chromatography of high purity conjugated fatty acid
摘要 A method for providing a purified conjugated fatty acid is disclosed. The purified conjugated fatty acid is formed by separating by liquid chromatography a conjugated fatty acid formed by a novel synthesis of reacting an ester of a fatty acid having a four carbon chain such that carbon one bears one hydrogen and one hydroxyl group, carbon two bears two hydrogen atoms, and a double bond is positioned between carbon three and carbon four, with a tosyl chloride or a mesyl chloride to form a tosylate or mesylate of said ester, and reacting the tosylate or mesylate of said ester with diazabicyclo-undecene. Reacting an ester of a fatty acid having a four carbon chain such that carbon one bears one hydrogen and one hydroxyl group, carbon two bears two hydrogen atoms, a double bond is positioned between carbon three and carbon four, with a tosyl chloride or a mesyl chloride to form a tosylate or mesylate of said ester, and reacting the tosylate or mesylate of said ester with diazabicyclo-undecene forms a conjugated fatty acid having a purity greater than 50%, and separating by liquid chromatography forms a conjugated fatty acid having a purity greater than 90%. In one aspect, the liquid chromatography uses a strong acid macroreticular ion exchange resin. In one aspect, the liquid chromatography includes silver ion liquid chromatography.
申请公布号 US6410763(B1) 申请公布日期 2002.06.25
申请号 US20000721849 申请日期 2000.11.24
申请人 SEIDEL MICHAEL C. 发明人 SEIDEL MICHAEL C.
分类号 C07C51/42;C07C303/28;C07C309/73;(IPC1-7):C11B7/00 主分类号 C07C51/42
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