发明名称 |
Histochrome and its therapeutic use in acute myocardial infarction and ischemic heart disease |
摘要 |
A pharmaceutical composition is provided, which comprises an aqeous solution containing a mixture of di- and tri-sodium salts of echinochrome in an amount of 0.90 to 1.10 g/ml (Histochrome). It meets the requirements that apply to injectable formulations. Administration of Histochrome reduces by 57% the necrosis zone in patients with acute myocardial infarction, restores the contractility of the left ventricle, reduces the incidence of reperfusion-induced ventricular arrhythmias and exerts an antiarrhythmogenic effect. Histochrome suppresses the aggregation of erythrocytes and thrombocytes, produces a beneficial effect on the clinical course of the disease, reduces the incidence of complications and lethal outcomes in cases of acute myocardial infarction. It is well tolerated by patients.
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申请公布号 |
US6410601(B2) |
申请公布日期 |
2002.06.25 |
申请号 |
US20010832864 |
申请日期 |
2001.04.12 |
申请人 |
TIKHOOKEANSKY INSTITUT BIOORGANICHESKOI KHIMII DALNEVOSTOCHNOGO OTDELENIYA ROSSIISKOI AKADEMII NAUK |
发明人 |
ELYAKOV GEORGY BORISOVICH;MAXIMOV OLEG BORISOVICH;MISCHENKO NATALYA PETROVNA;KOLTSOVA EVGENIA ALEXANDROVNA;FEDOREEV SERGEI ALEXANDROVICH;GLEBKO LJUTSIA IGNATIEVNA;KRASOVSKAYA NATALYA PETROVNA;ARTJUKOV ALEXANDR ALEXEEVICH |
分类号 |
A61K9/08;A61K31/122;A61K35/60;A61P9/10;(IPC1-7):A61K31/12 |
主分类号 |
A61K9/08 |
代理机构 |
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