Treatment of skin conditions by use of PPARalpha activators

摘要

Disorders of the skin and mucous membrane that have a disrupted or dysfunctional epidermal barrier are treated or prevented by topical application of compounds that are either activators of the farnesoid X receptor, activators of the peroxisome proliferator-activated receptor alpha, and oxysterol activators of the LXRalpha receptor. The same compounds are also effective in treating disorders of epidermal differentiation and proliferation.