Antiviral compounds

摘要

The present invention provides compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

主权项

1. A method for the treatment of HCV infection of a subject in need thereof which method comprises administering to such subject an effective amount of a compound of formula Iwherein:A is CH or N;n is 1 or 2;
R1 is lower alkyl, cycloalkyl, phenyl, or heterocycloalkyl;R2 is —C(═O)OR2′, —C(═O)N(R2′)2, monocyclic or bicyclic heteroaryl, optionally substituted with one or more R2′;
each R2′ is independently H, lower alkyl or heterocycloalkyl;R3 is H or lower alkyl;R4 is hydroxyl or amino; andX is CH2 or C(═O);
or a pharmaceutically acceptable salt thereof.