摘要 |
and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating D1-mediated (or D1-associated) disorders including, e.g., schizophrenia (e.g., its cognitive and negative symptoms), cognitive impairment (e.g., cognitive impairment associated with schizophrenia, AD, PD, or pharmacotherapy therapy), ADHD, impulsivity, compulsive gambling, overeating, autism spectrum disorder, MCl, age-related cognitive decline, dementia, RLS, Parkinson's disease, Huntington's chorea, anxiety, depression, MDD, TRD, bipolar disorder, chronic apathy, anhedonia, chronic fatigue, post-traumatic stress disorder, seasonal affective disorder, social anxiety disorder, post-partum depression, serotonin syndrome, substance abuse and drug dependence, drug abuse relapse, Tourette's syndrome, tardive dyskinesia, drowsiness, excessive daytime sleepiness, cachexia, inattention, sexual dysfunction, migraine, SLE, hyperglycemia, atherosclerosis, dislipidemia, obesity, diabetes, sepsis, post-ischemic tubular necrosis, renal failure, hyponatremia, resistant edema, narcolepsy, hypertension, congestive heart failure, postoperative ocular hypotonia, sleep disorders, and pain. |
申请人 |
PFIZER INC. |
发明人 |
BRODNEY, MICHAEL AARON MA;DAVOREN, JENNIFER ELIZABETH JE;DOUNAY, AMY BETH AB;EFREMOV, IVAN VIKTOROVICH IV;GRAY, DAVID LAWRENCE FIRMAN DLF;GREEN, MICHAEL ERIC ME;HENDERSON, JACLYN LOUISE JL;LEE, CHEWAH C;MENTE, SCOT RICHARD SR;ONEIL, STEVEN VICTOR SV;ROGERS, BRUCE NELSEN BN;ZHANG, LEI |