BIOTRANSFORMATION OF BIOLOGICALLY ACTIVE COMPOUNDS MADE OF VARIOUS CLASSES OF CHEMICAL SUBSTANCES BY MEANS OF LACCASE AND MANGANESE PEROXIDASE ENZYMES

摘要

The invention relates to a method for producing biologically active ingredients. Active ingredients comprising additional functional groups, a modified spectrum of activity and modified application properties can be obtained from medicaments or plant protection agents in the form of substrates which, as functional groups, carry at least one amino or hydroxyl group. Said active ingredients can be obtained by means of a one-electron reaction which is catalysed using enzymes or mixtures exhibiting enzymatic activity with a broad substrate spectrum. The method is characterised in that radical-forming enzymes are used as enzymes, and/or supernatants of ligninolytic mushrooms in an aqueous solution are used as mixtures exhibiting enzymatic activity. The following can be introduced in the form of additional functional groups: A) polyfunctional synthones which give the active ingredient a different solution behaviour in aqueous and lipophile systems, and high interfacial activity, B) aromatic molecules and heteroaromatic compounds, C) heterocyclic compounds, D) active ingredients with independent biological efficacy, and E) active ingredients which bring together independent activity and surfactant properties in one molecule. Together, said additional functional groups and the starting products produce covalently linked coupling products exhibiting modified distribution behaviour, by means of which polyfunctional interaction with the target organism is made possible.