发明名称 Prodrug acid esters of [2-(4-benzyl-3-hydroxy-piperidin-1-yl)-ethansulfonyl]phenol
摘要 The invention is a compound of the formulawhereinR isa) -C(O)(CH2)nC(O)OH,b) wherein R1 is -N(R2)(R3), or is a five or six member aromatic or non-aromatic heterocyclic ring having one or more heteroatoms selected from nitrogen, oxygen or sulfur, unsubstituted or substituted by lower alkyl,c) -P(O)(OH)2, or isd) -C(O)(CH2)nNHC(O)(CH2)nN(R2)(R3); andR2/R3 are hydrogen or lower alkyl;n is 1, 2, 3 or 4;or a pharmaceutically acceptable acid addition salt thereof
申请公布号 US6407235(B1) 申请公布日期 2002.06.18
申请号 US20010931431 申请日期 2001.08.16
申请人 HOFFMANN-LA ROCHE INC. 发明人 ALANINE ALEXANDER;BUETTELMANN BERND;FISCHER HOLGER;NEIDHART MARIE-PAULE HEITZ;HUWYLER JOERG;JAESCHKE GEORG;PINARD EMMANUEL;WYLER RENé
分类号 A61K31/445;A61K31/496;A61K31/5377;A61K31/675;A61P25/14;A61P25/16;A61P25/18;A61P25/22;A61P25/24;A61P25/28;A61P43/00;C07D211/42;C07F9/09;C07F9/59;(IPC1-7):C07D211/42;C07D403/12;C07D413/12 主分类号 A61K31/445
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