发明名称 |
PROTEIN:PRENYL TRANSFERASE INHIBITOREN |
摘要 |
<p>The invention pertains to novel peptide analogues suitable for inhibiting protein:prenyl transferased. The analogues comply with the following formula: <CHEM> in which: R<1> is hydrogen or a thiol-protecting group; R<2> and R<3> are independently hydrogen or C1-C4 alkyl; R<4> is hydrogen, C1-C4 alkyl, C1-C4 acyl or peptidyl; R<5> is hydrogen or C1-C4 alkyl; R<6> is hydrogen or optionally substituted C1-C6 alkyl; A is a direct bond or an optionally substituted C1-C4 alkylene chain; Y represents an oxo group or two hydrogen atoms; Z is oxygen, sulphur, imino or C1-C8 alkyl-, aryl- or acylimino; m is 0, 1 or 2; n is 0 or 1.el</p> |
申请公布号 |
AT219072(T) |
申请公布日期 |
2002.06.15 |
申请号 |
AT20000200372T |
申请日期 |
2000.02.03 |
申请人 |
NEDERLANDSE ORGANISATIE VOOR TOEGEPAST- NATUURWETENSCHAPPELIJK ONDERZOEK TNO;RIJKSUNIVERSITEIT LEIDEN |
发明人 |
OVERKLEEFT, HERMAN STEVEN;VERHELST, STEVEN HENDRIK LEONARD;MEEUWENOORD, NICOLAAS JOHANNES;PIETERMAN, ELSBET JANTINE;COHEN, LOUIS HARTOG;OVERHAND, MARK;VAN DER MAREL, GIJSBERT ARIE;VAN BOOM, JOCOBUS HUBERTUS |
分类号 |
C12N9/99;A61K31/351;A61P35/00;A61P43/00;C07D307/24;C07D309/10;(IPC1-7):C07D309/10 |
主分类号 |
C12N9/99 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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