发明名称 |
FUSED HETEROAROMATIC GLUCOKINASE ACTIVATORS |
摘要 |
Glucokinase activating compounds or pharmaceutically acceptable salts of Formula I-0: wherein M is Formula II or Formula III; Q is Formula IV or Formula V; R1 is an alkyl having from 1 to 3 carbon atoms; R2 is hydrogen, halo, nitro, cyano, or perfluoro-methyl; R3 is a cycloalkyl having from 4 to 7 carbon atoms or 2-propyl; R5 is halogen; R6 is halogen; W is O, S or NH; each Y is independently CH or N; Z is CH2-CH2-CH2-CH2 or CH=CR4-CH=CH-, wherein R4 is hydrogen, halo, or an alkyl sulfone having from 1 to 3 carbon atoms; and dotted lines collectively represent O or 2 additional double bonds in the heterocyclic ring structure. Compounds of Formula 1-0 may be present either as a racemate or in the isolated "R" configuration at the asymmetric carbon shown.
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申请公布号 |
CA2429642(A1) |
申请公布日期 |
2002.06.13 |
申请号 |
CA20012429642 |
申请日期 |
2001.11.28 |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
CORBETT, WENDY LEA;GRIMBSY, JOSEPH SAMUEL;SARABU, RAMAKANTH;HAYNES, NANCY-ELLEN;KESTER, ROBERT FRANCIS;MAHANEY, PAIGE ERIN |
分类号 |
A61K31/4184;A61K31/423;A61K31/428;A61K31/47;A61P3/10;C07D215/38;C07D235/30;C07D263/58;C07D277/82;(IPC1-7):C07D263/58;A61K31/418 |
主分类号 |
A61K31/4184 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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