发明名称 |
Verfahren zur Herstellung von Trans-4-Hydroxy-L-Prolin |
摘要 |
<p>Provided is a process for industrially producing trans-4-hydroxy-L-proline, which is useful as a raw material for medicines or as an additive to foods. In the process, L-proline is converted into trans-4-hydroxy-L-proline in the presence of an enzyme source which is derived from a microorganism belonging to the genus Dactylosporangium or Amycolatopsis and which catalyzes the hydroxylation of L-proline into trans-4-hydroxy-L-proline, a divalent iron ion and 2-ketoglutaric acid, in an aqueous medium, and the produced trans-4-hydroxy-L-proline is collected from the aqueous medium. Also provided is a novel enzyme L-proline-4-hydroxylase, which is useful for the process.</p> |
申请公布号 |
DE69429396(T2) |
申请公布日期 |
2002.06.13 |
申请号 |
DE1994629396T |
申请日期 |
1994.09.06 |
申请人 |
KYOWA HAKKO KOGYO CO., LTD. |
发明人 |
OZAKI, AKIO;MORI, HIDEO;SHIBASAKI, TAKESHI;ANDO, KATSUHIKO;CHIBA, SHIGERU |
分类号 |
C12N9/02;C12P13/24 |
主分类号 |
C12N9/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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