SCREENING METHOD FOR ROS-INDUCED APOPTOSIS IN A CELL

摘要

The invention relates to a system for modelling ROS-induced apoptosis in a cell, said system comprising: a) the provision of a population of cells; b) the exposure of said cell population to one or more stimuli which lead the cell population to undergo ROS-induced apoptosis; c) optionally, the exposure of said cell population to one or more inhibitors of ROS-induced apoptosis; d) the analysis of gene expression in the cell population; and e) the assessment of the onset of apoptosis in said cell population; and methods for identifying genes associated with ROS-induced apoptosis using such a system.