| 摘要 |
The present invention provides various covalently modified hemoglobin compositions, each having a low temperature-dependent oxygen-binding function. The present invention also provides methods for preparing the hemoglobin compositions wherein a hemoglobin is intra-molecularly cross-linked and covalently modified with a class of hydrodynamic volume-enhancing, anionic compounds. The present invention also provides therapeutic, oxygen-delivering compositions comprising the hemoglobin compositions and pharmaceutically useful vehicles. Moreover, the present invention provides methods for delivering oxygen to cells or tissues using these compositions.
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