Antipsychotic heterocycle compounds

摘要

Compounds of Formula I are useful antipsychotic and antidepressant agents demonstrating potent inhibition of 5-HT reuptake and dopamine D2 receptor antagonism. Ar-Y-(CH2)m-Z I In Formula I: Ar is selected from Z is II or III; Y is sulfur or oxygen; R1 and R4 are independently selected from H and lower alkyl; R2, R3, R6 and R7 are independently selected from H, halogen, and lower alkoxy; R5 is selected from H, halogen, lower alkoxy and cyano; m is an integer from 2-6; n is zero or the integer 1 or 2; and a dotted line represents an optional double bond.