发明名称 |
Rapidly disintegrating oral formulation of a cyclooxygenase-2 inhibitor |
摘要 |
A molded article such as a tablet is provided for administration to an oral cavity of a subject to treat or prevent a cyclooxygenase-2 mediated condition, disorder or disease. The molded article comprises a moldable blend of a therapeutically effective amount of a selective cyclooxygenase-2 inhibitory drug with a pharmaceutically acceptable excipient carrier system consisting predominantly of one or more carbohydrates, wherein ingredients and amounts thereof in the molded article and a process for preparing the molded article are selected such that the molded article exhibits rapid disintegration in the oral cavity, and wherein the moldable blend is prepared by a process step not requiring wet granulation.
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申请公布号 |
US2002071857(A1) |
申请公布日期 |
2002.06.13 |
申请号 |
US20010932537 |
申请日期 |
2001.08.17 |
申请人 |
KARARLI TUGRUL T.;KONTNY MARK J.;LE TRANG T. |
发明人 |
KARARLI TUGRUL T.;KONTNY MARK J.;LE TRANG T. |
分类号 |
C07D237/04;A61K9/00;A61K9/20;A61K31/341;A61K31/352;A61K31/415;A61K31/42;A61K31/444;A61K31/451;A61K31/485;A61K31/50;A61K45/08;A61K47/10;A61K47/26;A61K47/36;A61K47/38;A61P11/06;A61P19/02;A61P29/00;C07D213/61;C07D231/12;C07D261/08;C07D307/58;C07D311/58;(IPC1-7):A61K31/415;A61K31/353;A61K31/12 |
主分类号 |
C07D237/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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