COMPLEXES OF BRCA AND STAT POLYPEPTIDES AND METHODS OF USE IN THE DETECTION AND TREATMENT OF CANCER

摘要

The invention provides a method of inhibiting cellular proliferation mediated by a BRCA/STAT complex. The method consists of contacting a BRCA/STAT- containing cell with an effective amount of a BRCA/STAT complex modulating compound sufficient to modulate the amount or activity of a BRCA/STAT complex in the cell. The invention also provides a method of reducing the severity of cancer. The method consists of administering to an individual an effective amount of a BRCA/STAT complex modulating compound sufficient to modulate the amount or activity of a BRCA/STAT complex in cancer cells in the individual. Also provided are methods of detecting the risk of breast cancer in an individual. In one embodiment, the method consists of detecting an amount or activity of a BRCA/STAT complex in a sample obtained from an individual suspected of having breast cancer and comparing the amount or activity of the BRCA/STAT complex from the sample to an amount or activity form a reference sample, a difference in the amount or activity between the sample and the reference sample indicating the presence or susceptibility of breast cancer. The invention also provides methods of prognosing the severity or progression of breast cancer.