发明名称 |
Improved oral delivery of peptides using enzyme-cleavable membrane translocators |
摘要 |
Bioavailability of peptide active agents to be administered orally is enhanced by a pharmaceutical composition providing targeted release of the peptide to the intestine in addition to having the active peptide linked to a membrane translocator which is capable of being at least partially cleaved in vivo by an enzyme. The composition includes an acid-resistant protective vehicle which transports components of the invention through the stomach and a sufficient amount of a pH-lowering agent to lower local intestinal pH. All components are released together into the intestine with the peptide. |
申请公布号 |
AU2706002(A) |
申请公布日期 |
2002.06.11 |
申请号 |
AU20020027060 |
申请日期 |
2001.11.30 |
申请人 |
UNIGENE LABORATORIES, INC. |
发明人 |
WILLIAM STERN;NOZAR M. MEHTA;MARTHA V.L. RAY |
分类号 |
A61K9/16;A61K9/48;A61K38/00;A61K38/22;A61K38/23;A61K38/26;A61K38/28;A61K47/12;A61K47/14;A61K47/18;A61K47/24;A61K47/30;A61K47/42;A61K47/48;A61K49/08;A61K49/10;A61K49/12;A61K49/14;A61K49/18;A61P3/08;A61P3/10;A61P3/14;A61P5/18;A61P5/48 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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