发明名称 |
Regioselective synthesis of 2'-O-modified nucleosides |
摘要 |
Methods for the regioselective alkylation at the 2'-hydroxy position over the 3'-hydroxy position of nucleosides and nucleoside analogs, forming 2'-O-ester modified compounds, are disclosed. Reduction and derivatization of the 2'-O-ester provides 2'-O-modified nucleosides and nucleoside analogs useful for the synthesis of oligomeric compounds having improved hybridization affinity and nuclease resistance.
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申请公布号 |
US6403779(B1) |
申请公布日期 |
2002.06.11 |
申请号 |
US19990227782 |
申请日期 |
1999.01.08 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
KAWASAKI ANDREW M.;FRASER ALLISTER S.;MANOHARAN MUTHIAH;COOK P. DAN;PRAKASH THAZHA P. |
分类号 |
C07H19/06;C07H19/16;(IPC1-7):C07H21/02;C07H19/00 |
主分类号 |
C07H19/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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