发明名称 |
Humanised antibodies and uses thereof |
摘要 |
A humanised antibody capable of binding to the MUC1 mucin antigen comprises a light chain and a heavy chain. The variable region of the light chain (VL) comprising an amino acid sequence which is substantially homologous with the sequence of <cross-reference target="DRAWINGS">FIG. 1A</CROSS-REFERENCE> and the variable region of the heavy chain (VH) comprising an amino acid sequence which is substantially homologous with the sequence of <cross-reference target="DRAWINGS">FIG. 1B</CROSS-REFERENCE>. The amino acid residue at position 46 on VL is backmutated to arginine, and the amino acid residue at position 47 on VH is backmutated to leucine. The humanised antibody has use in the diagnosis and/or treatment of cancer. |
申请公布号 |
AU2084302(A) |
申请公布日期 |
2002.06.11 |
申请号 |
AU20020020843 |
申请日期 |
2001.11.29 |
申请人 |
THE UNIVERSITY OF NOTTINGHAM;CRC TECHNOLOGY LIMITED |
发明人 |
BENNY KWAN CHING LO;CHARLES ANTHONY LAUGHTON |
分类号 |
A61K51/10;C07K16/18;C07K16/30 |
主分类号 |
A61K51/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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