| 摘要 |
<p>The invention relates to medicine, in particular to pharmaceutical compositions for long acting tablets and to production methods thereof. The inventive pharmaceutical composition comprises microcapsules of a medicinal substance 96.0-99.2 mass %, a lubricant 0.1-1.0 mass %, water 0.1-3 mass % and an expander 0.1-1.0 mass % with respect to total mass of a mixture. Each microcapsule comprises the medicinal substance (96.0-99.2 mass %) and a film-forming material (0.8-4.0 mass %). The inventive method consists in producing the microcapsules by applying envelopes made of the film forming material to nonaglomerated particles of the medicinal substance and adding the lubricant and the expander. The moisture of the envelope is equal to or less than 0.5 mass %. Prior to adding the lubricant and the expander, the microcapsules are moisturised in order to obtain a moisture of 0.1-3 mass %. The lubricant being introduced into the mixture, the expander is added in the form of a cut fraction of the medicinal substance.</p> |
