METHOD FOR STUDYING THE EFFECTS OF COMMENSAL MICROFLORA ON MAMMALIAN INTESTINE AND TREATMENTS OF GASTROINTESTINAL-ASSOCIATED DISEASE BASED THEREON

摘要

a method of investigating chemical changes resulting from commensal microflora colonisation of mammalian intestine which comprises: a) measuring gene expression in commensal bacterium-colonized and germ-free intestine of at least one gene; and b) identifying a gene from a) that has at least a 2-fold difference in expression level between commensal bacterium-colonized and germ-free intestine. The method selects genes for further evaluation, and gives rise to the development of prophylactic treatments.