TRANSGENIC OR RECOMBINANT NON-HUMAN MAMMALS AND THEIR USES IN SCREENING PSYCHO-ACTIVE MEDICINES

摘要

The invention concerns transgenic or recombinant non-human mammals, wherein the expression of the gene coding for a microtubule associated protein (MAP) is modified (STOP gene) (inactivation or overexpression) and their uses in screening medicines useful in schizophrenia and schizo-affective disorders, with anxious, paranoiac or depressive component.