Camptothecin compounds which are effective anti-tumor compounds are disclosed. These conjugates inhibit the enzyme topoisomerase I and enhance the stability of the topoisomerase I-DNA cleavable complex.
申请公布号
WO0240040(A1)
申请公布日期
2002.05.23
申请号
WO2001US42951
申请日期
2001.11.16
申请人
RESEARCH TRIANGLE INSTITUTE;DUKE UNIVERSITY;NATIONAL INSTITUTES OF HEALTH